Post-traumatic stress disorder (PTSD) is characterized by poor .. The child showed significant relief of the symptomatology using CBD oil. September 26, By admin Comments are Off cannabis oil and PTSD, getting over post-traumatic stress disorder, medical issues cannabis oil treats. PTSD (Post Traumatic Stress Syndrome) of Cannabidiol Oil for Pediatric Anxiety and Insomnia as Part of Posttraumatic Stress Disorder: A Case Report.
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The answer was not surprising, and several studies were published showing that eCB system potentialization could in fact facilitate fear extinction in different behavioral tasks Chhatwal et al. Given that, according to Bisogno et al. The answer once again was affirmative, and since then studies have shown that CBD can facilitate the extinction of aversive memories not only in animals Bitencourt et al.
However, it is important to note that some studies suggest that the reduced expression of fear caused by CBD may result mostly from blocked reconsolidation of an aversive memory than its increased extinction Stern et al.
Regardless of which stage of aversive memory processing CBD affects, it appears that, at least in animals, this compound interferes with memory processing in a way that potentially mitigates damaging responses.
In addition to the possibility of CBD affecting different processes involved in aversive memory, animal studies also show favorable effects of this compound in the control of other frequent manifestations of PTSD symptomatology, such as sleep disorders.
Studies in rats indicate that CBD may contribute to an increase in sleep duration and depth, and a decrease in anxiety responses induced by sleep disturbance Monti, ; Hsiao et al. However, a thorough review of CBD and anxiety lies beyond the scope of this paper. The interested reader may want to see recent reviews by Blessing et al.
Research has also been moving in this direction, as we will see in the next section. Confirming animal study results in humans is essential for the validation of any strategy that demands a pharmacological therapy. In a study published by Das et al. Using inhaled CBD at a dose of 32 mg , a study in a model of aversive conditioning showed that the compound caused a reduction in the skin conductance response as well as in the expectation levels for the CS during new exposure. Consistent with results of animal studies, these findings show that CBD may be a pharmacological complement to be used in exposure-based therapy.
An important consideration in relation to this study is that CBD facilitated the extinction of aversive conditioning only when administered immediately after, and not before, the process. Therefore, understanding at which moment exposure-based therapy with CBD should start is one of several issues that still need to be resolved Das et al.
A case report published in by Shannon and Opila-Lehman described a year-old child who developed PTSD after being sexually abused before the age of five. The child showed significant relief of the symptomatology using CBD oil. Before the CBD therapy, the child underwent standard pharmacological treatment for the condition, which produced short-lasting partial relief, as well as significant side effects.
However, CBD oil given at a dose of 12—25 mg once a day appeared to relieve key symptoms, such as anxiety and sleep disturbance, while inducing minimal side effects. Although CBD is considered safe Bergamaschi et al. However, it is not possible to analyze the proportion of CBD and THC in the plant used by the patients in these studies.
Recent studies also point to a link between Cannabis use, possibly as a form of self-medication, and the occurrence of trauma-related events both in adolescents Bujarski et al. The more severe the traumatic experience, the greater the plant consumption Kevorkian et al. These findings may reinforce the theory that the entourage effect may be more important to the therapeutic effects of the plant than any single compound used in isolation. To confirm this theory, more studies are required for a review of Cannabis use in people with traumatic experiences, see Zer-aviv et al.
The mechanisms of CBD action in behavioral responses related to trauma are still unclear. Understanding the mechanisms underlying CBD action, for example on the expression of aversive memories, is important because a better understanding of this phenomenon may lead to the possibility of more effective interventions in traumatic memories in PTSD.
Several mechanisms of action have been proposed to explain the pharmacology of CBD and, as we shall see, they are far from universally accepted. Based on this assumption and taking into account different studies showing that the activation of CB1 receptors decreases the expression of behaviors related to aversive memories in rats Chhatwal et al. A recent review by Hill et al. Furthermore, animal studies have confirmed the importance of the CB1 receptor in mediating the effects of CBD on behavioral responses related to potentially traumatic memories Bitencourt et al.
However, other research has shown that the answer will not be that simple. In a systematic search of the extant literature for original articles on the molecular pharmacology of CBD, we found a study by Ibeas Bih et al. The authors show that CBD can act through 65 discrete, specific molecular targets, including 10 receptors, 32 enzymes, 10 ion channels, and 13 transporters.
With regard to the possible modulation of the eCB system, a study published by Massi et al. Nevertheless, because FAAH activity appears to be increased by chronic restraint stress in animal models as well as by anxiety-like behaviors Hill et al. In any case, a great deal of caution is needed when interpreting in vitro assays and, especially, when extrapolating in vitro results to the in vivo effects of CBD.
This mechanism may be the most promising possibility to explain at a molecular level the inhibitory effects of CBD on behavioral responses related to the recall of traumatic events and it is worth further investigation. However, controversy regarding the effects of CBD on serotonergic transmission remains. A study by Rock et al. In this study, the authors suggested that the 5HT 1A -mediated effects of CBD might involve allosteric interactions with the receptor binding site or interference with intracellular pathways Rock et al.
The possible interaction of CBD with the serotonergic receptor, also observed in the eCB system, has not been confirmed in vivo Ibeas Bih et al. Another molecular target, still less explored, that may mediate, at least in part, the effects of CBD on the expression of aversive memories, is the adenosinergic system. It has now been established that the blocking of the eCB system leads to an increase in the expression of fear responses, whereas eCB system stimulation causes a decrease in such responses.
Drawing parallels between eCB and adenosinergic signaling, adenosinergic receptor stimulation direct or indirect may represent an alternative treatment for trauma-related psychiatric disorders. Moreover, indirect stimulation of the adenosinergic system may explain the effects of CBD on aversive memories. Given the precariousness of the extrapolation of in vitro results to in vivo effects, the potential role of the adenosinergic system in the CBD-induced inhibition of aversive memory expression requires further investigation.
We are still far from reaching a consensus regarding the possibility of other molecular targets mediating the effects of CBD on aversive memories. Precisely for this reason, great care must be taken when interpreting the existing literature as well as proposing new experiments. In addition to the behavioral changes induced by treatment with CBD, some of which possibly mediated by the CB1 receptor, studies have also shown that chronic CBD treatment may facilitate neurogenesis in the hippocampus, a structure well known for its important role in processing memories Wolf et al.
Among the brain areas implicated in the effects of CBD, it is also important to highlight the amygdala, which is hyperactive in patients with PTSD and may be related to the severity of the symptoms Shin et al. CBD attenuated the level of blood oxygenation in the amygdalae of healthy subjects exposed to different levels of anxiety Fusar-Poli et al. Reduction in the hyperactivity of the amygdala may also explain, in part, the therapeutic effects of CBD against the symptoms caused by PTSD Passie et al.
The activity of the mPFC, a brain structure that plays an important role in the effects of CBD on the regulation of aversive responses Lemos et al. Finally, CBD-induced reduction of trauma-related responses raises a wide spectrum of possibilities involving multiple pharmacological and neural circuit mechanisms.
Understanding how these mechanisms work is just one more of the various challenges in the study of cannabinoids as potential treatment for neuropsychiatric disorders. Human and animal studies suggest that CBD may offer therapeutic benefits for disorders related to inappropriate responses to traumatic memories. The effects of CBD on the different stages of aversive memory processing make this compound a candidate pharmacological adjunct to psychological therapies for PTSD.
CBD also shows an action profile with fewer side effects than the pharmacological therapy currently used to treat this type of disorder. In addition, even at high doses, CBD does not show the anxiogenic profile of compounds that directly activate eCB transmission. However, even in the face of evidence pointing to the modulation of the eCB system, more studies are needed to develop a better understanding of the neurobiological mechanisms involved in CBD responses.
Although much remains to be discovered about the effects of CBD on PTSD symptoms many steps have already been taken in this direction, which may yield a formulation of CBD for the treatment of patients with trauma and stress-related disorders. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
The authors would like to thank Eduarda C. RB and RT are also grateful to Professor Elisaldo Carlini, pioneer of cannabinoid research in Brazil, for his invaluable contributions in this field of research. National Center for Biotechnology Information , U. Journal List Front Neurosci v. Published online Jul Author information Article notes Copyright and License information Disclaimer. This article was submitted to Neuropharmacology, a section of the journal Frontiers in Neuroscience.
Received Dec 28; Accepted Jul 3. The use, distribution or reproduction in other forums is permitted, provided the original author s and the copyright owner s are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Abstract Post-traumatic stress disorder PTSD is characterized by poor adaptation to a traumatic experience. Introduction Post-traumatic stress disorder PTSD is a chronic psychiatric condition that may develop after experiencing a potentially traumatic event.
Open in a separate window. Cannabinoids and Trauma-Related Disorder Cannabis sativa contains over compounds called phytocannabinoids. Facilitated extinction of contextual fear memory Via CB 1 receptors Lemos et al. Decreased acquisition of contextual fear memory Not shown Stern et al. Blockade reconsolidation of contextual fear memory Not shown Gazarini et al.
Blockade reconsolidation of contextual fear memory Not shown. Not shown Das et al. Not shown Shannon and Opila-Lehman, How Does It Work, Anyway? Conclusion and Future Perspectives Human and animal studies suggest that CBD may offer therapeutic benefits for disorders related to inappropriate responses to traumatic memories.
Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Acknowledgments The authors would like to thank Eduarda C. Cannabinoids modulate hippocampal memory and plasticity.
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CBD May Help PTSD
Survey: Cannabis Better Than Big Pharma Meds for PTSD The Use of Medicinal Marijuana for Posttraumatic Stress Disorder: A Review · CBD Modulates of Cannabidiol Oil for Pediatric Anxiety and Insomnia as Part of Posttraumatic Stress. Post-traumatic stress disorder, most common in war veterans, involves uncontrollable anxiety and flashbacks following a traumatic experience. Studies have. Suffering from Post Traumatic Stress Disorder but don't know where to start? Check out our newly updated guide to the best CBD oils for PTSD.