Mar 4, Cannabis (marijuana, pot, weed, grass etc.) is a widely used recreational and medicinal drug. In fact, cannabis use dates far back in ancient. Jul 17, Cannabis oil has been on the minds of men with prostate cancer. It seems that many people want to know if cannabis oil can cure prostate. Cannabis and cannabinoids have often been an issue of much polemics in the have been established to treat bone metastatic prostate cancer; some focus on.
With Help Can Prostate Cancer? CBD
I'm inherently lazy; I'll probably go along with whatever the docs recommend until such time as I'm unable to cope with it. As someone who can't have chemo or radio because my skin does not heal well and still going through operations to heal my scar from mastectomy 9 months ago I know these things are NO cure Sadly I have met people who claim cannabis cures cancer. This has happened more than once too. Love and peace to all.
Just think a lot of you all Skip to main content. Do you have a cancer chat password? Yes, I have a password. I would be happy to receive news and updates from Cancer Chat.
To continue using Cancer Chat, we need you to read and accept our updated Terms and Conditions. Leave this field blank. Not a member yet? Search for discussions or people. Hemp Oil 22 Apr I'm sorry to hear that you are struggling with cancer. We hope this information helps. Best wishes, Cancer Research UK. You're also correct in that it's expensive. In short, I'm an advocate of evidence based, conventional medicine. Numerous treatment options have been established to treat bone metastatic prostate cancer; some focus on treating the underlying pathophysiology, while others focus on pain management and palliative care.
More local modalities also considered in today's medical world are focal external beam radiation therapy, an excellent treatment choice for men with castrate-resistant prostate cancer and bone pain that is limited to one or a few sites, bone-targeted radioisotopes strontium 89Sr and samarium Sm for multiple blastic bone lesions, and radiofrequency ablation. Cannabis is a bushy plant with palmate leaves and clusters of small green flowers, and it grows wild in regions of tropical weather and can attain up to 3 m height.
The genus Cannabis is complemented by sativa which translates to useful. Cannabis has indeed been used throughout history for a variety of purposes, including the production of fiber for paper and textile manufacture. However, its current popularity lies in its use as a recreational drug with psychoactive properties.
The plant contains many chemical compounds that have different pharmacological properties, varying in quantity and quality depending on the strain, culture, and storage conditions.
In , Mechoulam and colleagues[ 14 ] found that deltatetrahydrocannabinol THC was the major psychoactive ingredient of cannabis. However, the endocannabinoid signaling system has only been the focus of medical research and considered a potential therapeutic target in recent times. Two different cannabinoid receptors have been described from mammalian tissues: The frequently held view of cannabis and its related products as drugs of abuse have slowed progress in the development of studies designed to take advantage of the properties of cannabinoid derivatives for therapeutic purposes.
The antagonizing effect of cannabinoids in the male reproductive system and physiology can be dated to where experimental models in male rats showed depression of spermatogenesis[ 21 ] and decrease in circulating testosterone levels. In recent years, cannabinoids and their derivatives have drawn renewed attention due to the discovery of diverse pharmacologic activities such as cell growth inhibition, anti-inflammatory effects, and tumor regression.
When the same cells were pretreated with cannabinoid receptor antagonists SR CB1 antagonist or SR CB2 antagonist , the coadministration of WIN, had no effect on cell viability, exhibiting a significant protective effect. Androgens are involved in the maintenance and progression of prostate cancer, where the androgen receptor is assumed to be the essential mediator for androgen action. Curiously enough it was determined that high cannabinoid CB1 receptor immunoreactivity is associated with greater disease severity and poorer outcome in prostate cancer patients.
Patients with high CB1 receptor immunoreactivity showed a significantly worse survival rate than those with low CB1 receptor immunoreactivity hazard ratio 2. A possible explanation for these results that is in synch with the cell line data is that the expression of CB1 receptors is regulated by the local endocannabinoid release.
The author's conclusion in this scenario was that a low endocannabinoid tone would allow for an increased rate of proliferation, resulting in a compensatory increase in surface expression of CB1 receptors. Cannabinoid CB1 receptors are found mainly in the central nervous system and, in less abundance, in certain peripheral tissues. Activation of presynaptic CB1 receptors in different brain regions or on primary afferents inhibits the release of neurotransmitters by decreasing calcium conductance and by increasing the conductance of potassium.
DeltaTHC is the substance with the greatest psychoactive potency of the natural cannabinoids and exhibits the greatest analgesic activity. Studies with CBD derivatives developed to inhibit peripheral pain responses and inflammation after binding to cannabinoid receptors have been described. Interestingly, some of these CBD derivatives did not have central nervous system effects, but maintained their antinociceptive and anti-inflammatory properties.
This means that centrally inactive synthetic CBD analogues may be candidates for the development of analgesic and anti-inflammatory drugs for peripheral conditions[ 53 ] without major central nervous system alterations of the sensorium. In animal models of cancer bone pain, synthetic cannabinoids reduced hyperalgesia by a CB1 receptor-mediated effect and possibly at the peripheral CB2 receptor. In some models, cannabinoids were superiorly effective in cancer pain when compared with other pain types.
Clinical trials have shown that nonselective cannabinoid receptor agonists are relatively safe and therapeutically efficacious, however, inducing also psychotropic side effects. Cannabinoid efficacy has also been studied clinically in cancer pain. Initial studies quantified the modest efficacy of oral 20 mg D9-THC equivalent to mg codeine with some sedation, dizziness, and confusion. Nabilone did not significantly increase adverse effects compared with the control group, and this fact could be attributed to the concurrent decrease in opioid dose.
Uncontrolled pain can cause unnecessary suffering, decreased ability to cope with illness, interference with daily activities and extended hospital admissions, and decreasing overall quality of life.
Step 1 of the ladder is for patients with mild to moderate cancer-related pain. These should first be treated with acetaminophen or a nonsteroidal antiinflammatory agent NSAID , possibly combined with an adjuvant drug that provides additional analgesia i. Step 2 describes patients with moderate or severe pain, including those who do not achieve adequate relief after a trial of an NSAID alone; these should be treated with an opioid. The analgesic ladder promoted the doctrine of using an opioid of inferior analgesic properties i.
On both steps 2 and 3, combination therapy that includes an NSAID or other drugs to enhance analgesia or treat side effects is advocated. The combination of two antinociceptive drugs acting through different specific receptor systems provides major benefits. When synergistic substances are given in combination, the required dose of each agent can be reduced to less than would be explained by mere addition of individual effects. The clinical benefit of this property is fundamental in analgesic treatments because effective pain relief can be achieved with minor, fewer, or no side effects.
Chronic pain is a difficult subject to approach both for the patient and the treating physician and, not uncommonly, leads to chronic opiate consumption and dependence. Cannabis has been documented to be one of such measures. As with any therapeutic modality, adverse effects must be taken into account. A number of patients will suffer from these, although most of them will be present within the first days of treatment and attenuate as they adjust to the drug.
Chronic cannabis use does not produce serious cognitive disorders, as occurs with other substances such as alcohol, but it can aggravate preexisting mental disease. Therefore, treatment with cannabinoid receptor agonist with central actions may be contraindicated, in individuals predisposed to or with current psychiatric disorders. No human deaths associated to cannabis use have been reported. Prostate cancer is a grave public health problem worldwide. For these reasons, it is fundamental to invest time and intellectual resources into finding new and novel targets for the treatment of prostate cancer.
It seems that the studies of Sarfaraz and colleagues lead to the direction that cannabinoids should be considered as agents for the management of prostate cancer, pending support from in vivo experiments. This would not only make sense from an anti-androgenic point of view but also for men with bone metastatic prostate cancer, perhaps from a pain management or palliative point of view.
Among the patients suffering with chronic pain and receiving opioids, one in five abuse prescription controlled substances,[ 69 , 70 ] and it is not difficult to see that opioid dependence and abuse is becoming a public health problem.
Different methods of managing pain should be addressed to avoid these scenarios. The presence of pain in men with advanced prostate cancer is an immediate indication for aggressive management with analgesics, while adequate treatments that address directly the cause of the pain are pursued. These compounds harbor analgesic properties that aid bone cancer pain, reduce opioid consumption, side effects, and dependence, as well as exhibiting anti-androgenic effects on experimental prostate cancer cells.
Cannabis sativa and its main active component deltaTHC have long been used for numerous purposes throughout history including medicinal, textile, and recreational. Since its legal banning in the United States in , it has become an issue of taboo and controversy, frowned upon for its recreational uses and psychotropic effects.
I cry at sight of my own face in mirror. I'm sorry to learn about your husband. I appreciate this must be an incredibly difficult time for you both. Without proper studies, it isn't possible to say how effective a treatment is. If a product is used as a medicine to treat a serious medical condition there needs to be evidence to show that it works.
Our freephone telephone number is We are here from Monday to Friday between the hours of 9am to 5pm. I think there's so much evidence now, those that can change things are starting to listen I know it's not for everyone I wasn't sure if you've recently talked to your doctor about your pain, do mention it to them if you are still having problems. So do talk to your medical team about this.
Anyone is free to chose what to do. But if you do a Google search you don't always come up with the sort of evidence that is gathered in a scientific way. Thanks for your reply I only mentioned I tried it It's just so nice to have a discussion about it and not dismissing people who want to try something when they have a terminal diagnosis I have a lot of other issues with health So hope yo don't mind me explaining my reply to you I have great respect for you wonderfull nurses..
I thank you for the detailed reply and i agree in part. Also we have placed trust time and again with nhs staff only to be mistreated, lied to and let down. How for example is shouting at a vulnerable family in crisis going to help anyone? Thank you for the offer of help though. Hi Chrissie I appreciate your reply to my post. I am grateful for all views in fact. I did print out the first few pages from the health rack website showing it is legal as a health food supplement but she was adamant it was illegal and started her shouting rant.
I should have manned up last time. This week hopefully will be different. I will have a look in the CR research engine but I have done a lot of poking around the internet or I would not have started his nibs on CBD in the first place. Been on it about 2 weeks now.
I have always wondered whether cannabis oil could indeed be a cure for prostate cancer. Unfortunately, I do not see in practice the desired beneficial effect and. Jan 9, for some time, but exciting new research suggests it could be capable of killing cancer cells. Find out how CBD can help treat Prostate Cancer. Sep 2, “The idea that cannabis would influence prostate cancer in a meaningful way sounds more than a little far-fetched to me,” Dr. Juurlink said in a.