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A System 3. Nervous Of Reset The
If this is less positive than that-- if I have a positive charge here, it's going to want to go to the less positive side.
It's going to want to go away from the other positive charges. It's repelled by the other positive charges. Likewise, if I had a negative charge here, it'd want to go the other side-- or a positive charge, I guess, would be happier being here than over here. But the question is, how does that happen? Because left to their own devices, the charges would disperse so you wouldn't have this potential gradient. Somehow we have to put energy into the system in order to produce this state where we have more positive on the charge of the outside than we do on the inside.
And that's done by sodium potassium pumps. I'm going to draw then a certain way. This is obviously not how the protein actually looks, but it'll give you a sense of how it actually pumps things out.
I'll draw that side of the protein. Maybe it looks like this and you'll have a sense of why I drew it like this. So that side of the protein or the enzyme-- and then the other side, I'll draw it like this. It looks something like this, and of course the real protein doesn't look like this. You've seen me show you what proteins really look like. They look like big clusters of things, hugely complex.
Different parts of the proteins can bond to different things and when things bond to proteins, they change shape. But I'm doing a very simple diagram here and what I want to show you is, this is our sodium potassium pump in its inactivated state. And what happens in this situation is that we have these nice places where our sodium can bind to.
So in this situation, sodium can bind to these locations on our enzyme or on our protein. And if we just had the sodiums bind and we didn't have any energy going into the system, nothing would happen.
It would just stay in this situation. The actual protein might look like something crazy. The actual protein might be this big cloud of protein and then your sodiums bond there, there, and there.
Maybe it's inside the protein somehow, but still, nothing's going to happen just when the sodium bonds on this side of the protein. In order for it to do anything, in order for it to pump anything out, it uses the energy from ATP.
So we had all those videos on respiration and I told you that ATP was the currency of energy in the cell-- well, this is something useful for ATP to do. ATP-- that's adenosine triphosphate-- it might go to some other part of our enzyme, but in this diagram maybe it goes to this part of the enzyme. And this enzyme, it's a type of ATPase.
It's able to plunk it off. When it plunks off the phosphate, it changes shape. So step one, we have sodium ions-- and actually, let's keep count of them. We have three sodium-- these are the actual ratios-- three sodium ions from inside the cell or the neuron. They bond to pump, which is really a protein that crosses our membrane. Now, step two, we have also ATP.
So that also provides energy to change pump's shape. Now this is when the pump was before. Now after, our pump might look something like this. Let me clear out some space right here. I'll draw the after pump right there. And so this is before. After the phosphate gets split off of the ATP, it might look something like this. Instead of being in that configuration, it opens in the other direction.
So now it might look something like this. And of course it's carrying these phosphate groups. They have a positive charge. It's open like this. This side now looks like this. So now the phosphates are released to the outside.
So they've been pumped to the outside. Remember, this is required energy because it's going against the natural gradient. You're taking positive charge and you're pushing them to an environment that is even more positive and you're also taking it to an environment where there's already a lot of sodium, and you're putting more sodium there.
So you're going against the charge gradient and you're going against the sodium gradient. But now-- I guess we call it step three-- the sodium gets released outside the cell. And when this changes shape, it's not so good at bonding with the sodium anymore.
So maybe these can become a little bit different too, so that the sodium can't even bond in this configuration now that the protein has changed shape due to the ATP. So step three, the three Na plusses, sodium ions-- are released outside. Now once it's in this configuration, we have all these positive ions out here. These positive ions want to get really as far away from each other as possible. They'd actually probably be attracted to the cell itself because the cell is less positive on the inside.
So these positive ions-- and in particular, the potassium-- can bond this side of the protein when it's in this-- I guess we could call it this activated configuration. So now, I guess we could call it step four. We have two sodium ions bond to-- I guess we could call it the activated pump-- or changed pump.
Or maybe we could say it's in its open form. So they come here and when they bond, it re-changes the shape of this protein back to this shape, back to that open shape. Now when it goes back to the open shape, these guys aren't here anymore, but we have these two guys sitting here and in this shape right here, all of a sudden these divots-- maybe they're not divots.
They're actually things in this big cluster of protein. They're not as good at staying bonded or holding onto these sodiums so these sodiums get released into the cell. So step five, the pump-- this changes shape of pump. Then surface electrodes from a TENS unit were applied.
The TENS unit was turned on in one group and not the other. Heart rate variability tests and muscle sympathetic nerve activity MSNA indicated if the status of their autonomic nervous systems changed. The electro-acupuncture-like treatment of the ear actually worked. Much work needs to be done to validate this approach in disease. Some other studies using different techniques or smaller sample sizes have not had significantly positive results, but one study using electroneurostimulation of the ear in coronary artery disease had impressive results.
After seven days their exercise intolerance had decreased enough and they were able to climb flights of stairs without suffering from angina.
The vagus nerve is a big deal in more ways than one. The anti-cholinergic functions of the vagus nerve make it a key part of the anti-inflammatory response. Low PNS activity is associated with increased inflammation, making it no surprise that reduced PNS activity is common in cardiovascular disorders. An over-active sympathetic nervous system, for instance, is believed to skew the immune response in the Th2 direction resulting in increased antibody production and decreased protection against intracellular pathogens.
Turning the SNS down could then improve antiviral defenses and reduce autoimmune processes. The very complex ANS system provides many opportunities for different things to go wrong. Decreased heart rate variability is associated with an increased risk of death — not just in people with cardiovascular disorders, but in the general population as well.
The next step for these researchers is testing the device in heart failure patients. Some studies have not been successful. It is, however, a non-invasive approach that does not appear to cause side effects and which may, this study suggests, have far-reaching effects on the autonomic nervous system.
You may not need a prescription drug, an electrical implant, or even an electrode taped to your ear to reduce your SNS and boost your PNS activity. I bet chanting would really stimulate the vagus nerve. Definitely worth a try! As a former patient- He is the biggest disappointment in any of my diagnosis. Completely set me back so much and was so wrong on so many levels it is scarey. Its is possible for oxygen to oxidize if the patient is highly toxic.
Likewise, some breathing exercises can be extremely harmful as can be some type of meditation.. Not all of us have the same physiology. But oxygen toxicity exists! Wish you all the best. One of the effective modalities I have found in my fifteen year search to balance SNS and PNS is the use of an alpha-stim device and addressing the polymorhisms that cause methylation disruption. Using Nutrigenomic concepts presented by Amy yasko and Rich Von Konynenburg I have found renewed energy, mental clarity and a reduction in fibro-pain to the point of enjoying and participating in life again.
Very grateful to all the people who participate in the quest to find some answers and share their knowledge. Sean L — which alpha-stim device did you you use? How do you use it? Anyone report any vertigo side effects with this stimulation? Get intermittent vertigo so am careful with ears and wrist accupressjre points Also, been over 4 years since this very nice opinion piece.
I want the vagus nerve stimulation. I have a practically dead intestinal system for almost 3 years. I am getting sicker every day. Where can I go to get this done. I live in PA near Philadelphia. I am so looking to try new therapies. If any doctor will see me; I would be so thankful. His name is Joseph A. Garabedian and he has done work with the likes of Dr.
Jacob Teitelbaum and Dr. Ken Holthorf, both of whom were also CFS sufferers. Garabedian and you will find lots of info on his protocol and practice. He also has an associate doctor and a nurse practitioner Andrea who is very good and not quite as expensive I believe.
Best wishes for coping with this painful affliction! G can find some things to help you feel at least a bit better.
I would say that my health ranges from 50 percent better on bad days to 75 percent better on good days than what I was before seeing him.
Yes, Dr Garabedian is wonderful, compassionate and helped me quite a lot. Also, Dr Chung at Chung Institute is excellent. Now although I still experience whole body pain etc. I was even able to find a Walgreen compounding pharmacy which is able to bill my Medicaid insurance for it.
Have you tried a pro-biotic? Any one work with BradYates YouTube? I have pTSD startle mode response Janet. Is there a way to know what points on the ear to treat?
If you try this, can you update us on your experience? You can see it on line under ear anatomy. Not all the charts have it but some do. The concha is the little bowl-shaped area beneath the tragus. You can see a picture of this at http: I did notice though, that the study used healthy controls, rather than people with CFS. Given that CFS seems to turn everything on its head, can we necessarily presume that transcutaneous stimulation of the vagus nerve would have the same calming effects or last as long as it does for healthy people?
It will require studies on sick people. Another mention of this study said they appled electrical pulses to the tragus, the small raised flap at the front of the ear immediately in front of the ear canal. A year ago this month I had a minor gyno surgery procedure done that I was dreading. I feared the anesthesia would mess me up and hurl me into yet another painful fibro relapse. Or worse yet, that my weak immune system would pick up some nasty infection while I was at the hospital.
To my great shock and surprise, my fibro pain greatly diminished after my surgery and flareups are now few and far between. I have honestly felt better this past year than I have in the past twenty! Has anyone else had a similar thing happen to them? What else could it have been? After all, if the reset button works on my computer, is it that far off to think it could work on me?
Maybe we all need to reboot! People with severe Complex Regional Pain Syndrome are sometimes put into a ketamine induced coma to reset their nervous systems. It works in a significant portion of them. I actually feel better — calmer and with more energy- after dental anesthesia: I have a tens machine very inexpensive and also a Fisher Wallace Cranial Stimulator. I may be my own guinea pig and try this. Anybody think this is a really bad idea, practicing on myself? Is not the entire ear be a useful site for accupressure work?
I suspect this is something known for millennia to the Chinese. Electro-acupuncture to the ear. However a quick google also turns up this for the US http: Possibly cheaper models available and you might want to look at the cost of replacement gel pads. I wonder if self administered acupressure of the tragus will help? I will certainly give it a try.
But the truly helpful intervention is beta-blockers — I would not function without them! I wonder how much relief cardiac patients will get from the TENS machine compared to beta-blockers. I look forward to more research on ill people. So arousal but no climax will be the thing if we want to rebalance the ANS. Funny — I was stuck with some obstinate thoughts last night that made it even more impossible to sleep, so I diverted attention by stimulating myself a bit.
This program had been available for yeas now. The basic idea is the same: This is what the whole program is designed to do — and it works: The ongoing support and optional extras live, interactive web broadcasts for example are very good. Aural acupuncture is a well developed speciality.
You can qualify without having any acupuncture training. There is a British professional association which regulates training standards — which are quite rigiorous- In Britain it is routinely used in the treatment of people struggling with the side effects of cancer chemotherapy to prevent nausea and for those being treated for addictions to RELAX.
Interesting that it has been used for years for this. I wrote about my own research and a chart I created further down this thread. I have absolutely no money for anything so am trying to find my own solutions. This is for me the one million dollar guestion. A psychologist recommended an Alpha Stim device for me. It induces alpha brain waves through electrodes attached to the ear lobe.
Will this also stimulate the vagus nerve? I have seen it said that it is hypothesized that the Alpha-Stim stimulates the vagus nerve. However, the vagus nerve has very few nerve endings in the earlobe area, where the Alpha-Stim is supposed to be attached. I tried the method described in this article using the TENS mode of a multi-purpose device that I had. The results were dramatic — far greater that those of the TENS unit.
During the treatment, everything looked brighter and sharper — an effect that Dr. Goldstein has reported his patients saying when he finds the pharmaceutical treatment for them that relieves all symptoms. Certainly, I felt fine during the treatment. I am going to continue using this treatment using the Alpha-Stim, and based on my experience and Dr. It is virtually impossible to attach the usual self adhesive pads to the small triangular ear flap.
I eventually managed to cut the pads as small as possible and with the help of a plastic clothes peg, some superglue and an ear hair trim I got something that works.
You can get the same ear clips used in the study at http: However, if you can get access to an Alpha-Stim, I have found the results to be much more powerful; please see my post above. Would love to try this, any ideas how? Please have a look at my chart for ear acupressure, link provided in a post further down.
I find you being so easily offended offensive!
Learn how to calm nerves and better manage your stress with these 6 ways to Step 3: 6 Ways to Hack Your Nervous System To Consciously Manage Stress. This activates our sympathetic nervous system, accelerating our adrenal If the body is in fight or flight, then chances are that you may need a system reset. Although this pranayama is also known as a three-part-breath, the. Nature can play a fundamental role in the photo 3 restoration of a healthy nervous system, providing an opportunity to re-set a hyper functioning.