A collection of published research articles and other educational resources about diabetes and CBD (cannabidiol). Recent studies provided compelling evidence that the newly discovered lipid . Recently, an interesting study investigated the effects of CB1 antagonist therapy in CBD reduced the incidence of diabetes in nonobese diabetic mice, the. Here is a list of research and studies on CBD and it's potential use for treating Diabetes. CBD for Diabetes: Neuroprotective and blood-retinal barrier-preservi.
Studies - & Diabetes Research CBD For
One unique factor that separates Cannabis from other illegal drugs is that the human body is equipped with an innate brain system that reacts to the THC and CBD enzymes. This system is called endocannabinoid system also known as EC system ; it is responsible for many body functions which includes cognition, emotions, motor coordination and movements, appetite, and reaction to responses.
And unlike other illegal chemicals that creates active damages to the neural receptors for example, LSD literally burns a hole in the brain by damaging neurons and brain cells that can be shown in x-rays photos , the cannabinoids are natural and have no physical damage to the human brain and body.
In fact, human breast milk naturally contains many of the same cannabinoids found in Cannabis. These chemicals are actually extremely crucial for development such as induce nutrition intake, stimulate brain cell formation, and protect body cells from harmful bacteria, virus, and even cancer formation. In the past, the THC cannabinoid enzyme has been the focused in many health studies concerning marijuana.
Although THC is known to have some healing properties, recent studies have shown that it is the cannabidiol enzyme CBD and its precursor enzyme CBDa CBD exists as CBDa before the heating or extraction process that carries much more medicinal value for many diseases ranging from psychological disorders, neuroprotective effects, rejuvenating properties, to anti-cancer healing abilities. Most people would think that an increased caloric intake would result in a higher BMI.
It would also be logical to assume that marijuana users tend to be overweight and prone to diabetes. Surprisingly, these two assumptions do not seem to apply to marijuana users. In order to determine whether or not the assumptions stand, an early medical correlation study was conducted to examine the effects of Cannabis use on blood glucose level and insulin level. In the study, subjects out of total participants were marijuana users. These participants showed a lower tendency to have diabetes than non-marijuana users.
This discovery answers how exactly Cannabis can benefit type 2 diabetic and pre-diabetic individuals. For individuals who suffer from obesity and type 2 diabetes , endocannabinoid imbalance may be one of the reason why certain people have a hard time losing weight.
It has been found that the endocannabinoid system has a role in regulating energy homeostasis especially in the intra-abdominal adipose tissue. When the endocannabinoid system is over-regulated, it may lead to excessive visceral fat accumulation in the stomach area and reduced adiponectin release from the tissue. Adiponectin is a protein that is responsible for regulating glucose levels and fatty acid breakdown.
The decreasing amount of adiponectin in the body can lead to insulin insensitivity and increases the chance of developing type 2 diabetes. This chain reaction can turn into a vicious cycle of insulin resistance, further endocannabinoid system activation, greater increase in appetite and food-seeking behavior , and additional body weight and fat gain.
Unlike THC that creates the munchies effect, CBD can help to suppress appetite and help individuals to re-balance the endocannabinoid system by increasing the fat breakdown, increase the mitochondria activities and promote metabolism, and decrease fat storage. In a way, CBD changes the white-colored fat storage cells to beige-colored fat cells for energy making. So not only is the fat much easier to be burned off, the beige-colored fat cells also improve glucose tolerance by decreasing insulin resistance in the muscle and liver cells.
Although it may not completely treat diabetes, CBD can alleviate the condition so that diabetic individuals can suffer from less blood glucose fluctuation and manage their blood glucose level with less medication. Another factor that CBD is a suitable treatment option for type 2 diabetes is that insulin resistance is a great contribution to the disease. Aside from CBD, THCV can also be a weight loss aide for type 2 diabetes individuals who are obese and need to lose weight to better control their blood glucose level and prevent complications from arising.
It was found that CBD exhibits anti-autoimmune abilities. Even though some non-specific immunosuppression medication have shown to be successful in preventing diabetes, they are not an ideal alternative. Suppressing the immune system in a general fashion for an extended amount of time would present a dangerous treatment. Moreover, these drugs indicated to be working only temporarily in the clinic until resistance was acquired.
The marijuana and diabetes research is a lot more promising. In fact, clinical studies have shown that CBD can save insulin-forming cells from damage so that normal glucose metabolism can occur. At the moment, scientists have successfully use CBD to reverse the auto-immune disease in mice that suffer from early stage of type 1 diabetes. They are in test trials to transfer this knowledge into treatments for human patients so that CBD can be a cure for type 1 diabetes.
Although Cannabis cannot cure type 1 diabetes currently, the THC enzyme can suppress the autoimmune attacks so that less insulin is needed to lower the blood glucose levels. At the same time, CBD has found to reduce the inflammation of pancreatic cells and THCV has shown to improve glucose tolerance and increase insulin sensitivity for type 1 diabetic individuals so that there is a possibility that less insulin is needed for the management and the fluctuation of the blood glucose level is more manageable.
To confirm these findings, another research was conducted in where obese rats lost significant weight and experienced an increase in pancreas weight after exposure to organic Cannabis extract.
The increase in the weight of the pancreas indicates that the insulin production pancreatic cells known as beta cells are protected by the presence of cannabinoids in type 1 diabetes. For many type 1 diabetes patient, stress and anxiety are a common problem that can aggravate the blood glucose level fluctuation. In general, many prediabetic patients have similar problem as type 2 diabetic individuals; they are very likely to suffer from obesity, poor eating habits , and lack of exercise.
Diabetes is associated with high levels of fasting insulin and insulin resistance and a low level of high-density lipoprotein cholesterol. These at-risk individuals may benefit from the health benefits offered by Cannabis products. Many research studies have found that the average regular Cannabis users tend to have a lower body mass index BMI than non-Cannabis users. They also have a smaller waist circumference than non-Cannabis users. At the same time, they have lesser chance of developing type 2 diabetes than those who do not use Cannabis.
This study suggests that Cannabis can not only help control diabetes but also prevent the onset of diabetes. Insulin resistance IR is a condition that makes body cells reject the normal functioning of insulin, a pancreatic hormone that is essential to the regulation of glucose metabolism.
Type 1 diabetic individuals are unable to produce insulin. Unlike type 1 diabetes, the insulin production is unaffected in type 2 diabetes individuals.
However, their body cells are ineffective at processing insulin or are unable to process it. When cells become insulin-resistant, they are incapable to absorb the glucose needed to supply the cells with energy. This reaction causes the unused glucose to build up in the bloodstream. If left untreated, this causes a downward spiral of chain reaction that consequently causes hyperglycemia.
A study conducted in has found that Cannabis users have a mean insulin resistance of 1. Current cannabis users are also discovered to have lower blood glucose levels compared to past users and non-users. These current Cannabis users have a mean blood glucose levels of On the other hand, past users have a mean blood glucose level of These conclusion highly suggest that Cannabis can help suppress insulin resistance and help type 2 diabetic individuals in managing their blood glucose level.
However, more research is needed to better understand how exactly does Cannabis help with this problem and whether it is THC, CBD, or other cannabinoids that actively helps in reducing insulin resistance. The American Alliance for Medical Cannabis AAMC has suggested that Cannabis has the ability to suppress arterial inflammation and prevent diabetic individuals from developing cardiovascular diseases.
The cannabinoids also have the ability to keep blood vessels to dilate so that circulation can be improved in the process. This can be a great prevention for individuals who are prone to swelling of the feet due to poor circulation. It can also help with spider veins, varicose veins, night cramps, restless leg syndrome, blood clots, ankle swelling, lipodermatosclerosis, and panniculitis. One of the most common problems that diabetic individuals face is skin sensitivity and irritation complications.
The cannabinoid inflammation suppression properties can help with skin inflammation problems. For those who have a tendency to suffer from foot sores, rashes, and other skin irritation problems, Cannabis can alleviate the complications and speed up the healing process.
As a matter of fact, several science studies have found THC to be beneficial to skin cancer. Other studies have documented the anti-aging and intense moisturizing properties of cannabinoid. The sedation and pain relief properties can also help alleviate the uncomfortable sensations from the skin irritation. Without constant scratching and rubbing on the irritated area, the skin can heal faster to lessen the chance for further complications.
Neuropathy refers to nerve damages caused by certain diseases or disorders. It is found in 60 to 70 percent of all individuals with diabetes. To be more specific, there are 4 types of diabetes-related neuropathy:. It is simply one of the worst complications for diabetic individuals. Although there are several treatment options available, none of them are sufficient in preventing neuropathy let alone reversing the complications. Several studies have shown vaporized Cannabis to reduce pain and slow the advancing nerve damage of all four types of neuropathy.
In some types, there was more than a 30 percent improvement without any significant impact on daily functioning or cognitive abilities. The anti-inflammation property does not just stop there. Some health researchers have also suggested that the cell growth acceleration ability can even reverse the neuropathy damages. Just like neuropathy, diabetic retinopathy is another common complication that makes life so much more difficult for diabetic individuals.
It has been shown in several studies that cannabidiol can work as a multi-tasker to protect the eyes from growing an excess of leaky blood vessels the number 1 symptom of diabetic retinopathy and prevent retinal cell death. There are even some researchers who suggest that CBD may even have cell growth ability to reverse the damage done by diabetes.
High blood pressure is often a complication of Type 2 diabetes. Although medical marijuana does lower blood pressure, it also briefly raises heart rate after consumption. As a result, Cannabis is not recommended for those individuals who have pre-existing heart conditions. Having said that, there are medical studies showing that prolonged marijuana users can develop a tolerance for this side-effect and they do not suffer any negative effects from the brief episode of quickened heart rate.
CBD is an effective treatment for mental health disorders such as anxiety, psychosis, and depression. Recent health studies have shown neurogenesis neural cell growth is a crucial neurological process that effectively helps to alleviate stress.
Similar to exercising, CBD facilitates neuron production. Some of the most well-known strains that have been effective treating with anxiety and stress-alleviation are Cannatonic, Frank Ocean, and Ghost Rider. At the same time, CBD offers an instant energy boost for the stressed individuals. Many high-functioning anxious individuals have found CBD heavy strains to be a new alternative to coffee without the jitteriness. It can also help to alleviate serious social anxiety.
For depressed individuals, the uplifting mood enhancing ability of CBD has known to offer a positive reinforcement so that they can feel better about themselves and their current situation.
Cannabis can be a treatment to prevent seizures in individuals who suffer from severe epilepsy. The cannabinoids have shown to significantly decrease both the severity and frequency of the seizures. In these cases, the affected children have become much more stabilized after starting a daily CBD concentrated tincture regimen.
One of the most famous case is a 5 year old girl named Charlotte Figi who suffers from Dravet syndrome. After the documentary on the case has been broadcasted on television and news article, more children who suffer from similar health problems have started similar cannabinoid therapies and have seen greater improvement in both physical and mental development within short amount of time. Similar to treating severely epileptic children with CBD oil, children who suffer from severe cases of autism can show great improvement with CBD oil treatment.
There have numerous cases where a non-verbal child develops significant verbal skills and exhibit much more social interaction as little as 3 weeks. One of the biggest discovery for Cannabis is that it can be a great treatment for various cancers. The Pacific Medical Center of San Francisco has made an important discovery that CBD is a powerful treatment to stop cancer cell proliferation, metastasis, and growth of tumors. A study done by Sean McAllister of the research center has shown breast cancer show that the number of cancer cells diminished as more CBD was applied.
Essentially, CBD may be a generally effective way to switch off the cancer-causing gene, providing patients with a non-toxic therapy to treat aggressive forms of cancer. There is one exception to the theory that CBD suppresses appetite, but it is a blessing as well. Many people who have difficulty eating due to their stress or anxiety can use CBD to get rid of that sick feeling in their chest or stomach, allowing them to eat again once their anxiety subsides.
Science research has shown that Cannabis can reduce vomiting and nausea for patients who are going through chemotherapy. It also helps to improve appetite and promote eating. Post-traumatic stress disorder is an anxiety condition caused by psychologically disturbing events such as sexual assault, severe accidents, and military combat. Individuals who suffer from PTSD can exhibit a combination of symptoms such as constant flashbacks of the traumatic event, active social isolation, anxiety attacks, insomnia, constant nightmares, depression, and emotional instability.
For these problems, CBD can help PTSD individuals to feel less anxious about their situation and feel motivated to carry on their daily activities. Depending on the individuals needs and symptoms, several strains of product may be needed provide sufficient treatment.
Also, further research studies have found that cannabinoids increases metabolism and promote more fat burning. At the same time, CBD is a great encouragement for users to get off the couch and exercise. Research studies done by the University of Nottingham have indicated that Cannabis can help protect brain and neural damage caused by a stroke.
By administrating Cannabis extract within short duration after the stroke, the affected area by the stroke has significantly reduce in size. These findings are consistent amongst rats, mice, and monkey test subjects. Further studies in have revealed that CBD can actively block the glutamate neurotoxin from killing brain cells during and after a stroke. As a matter of fact, CBD has shown to be even more effective than vitamin E and A in blocking the glutamate neural damage.
Similarly, this unique property allows CBD to help with individuals who have suffered from concussions and brain trauma. Since the early s, health research studies have found that Cannabis lowers the intraocular pressure IOP in both normal people and patients who suffer from glaucoma. By decreasing the pressure, the cannabinoids allows less damage to the optic nerve that eventually cause vision loss.
At the same time, it helps to alleviate various symptoms that are associated with glaucoma such as eye pain and nausea. By blocking the neural enzyme that produce the amyloid plaques, Cannabis can greatly decrease the progression of the disease. Cannabis has a long history of being used as a pain relief from chronic pain to muscle spasms to menstrual cramps.
As a matter of fact, a company backed by actor Whoopi Goldberg is in the works of creating a tampon that is infused with cannabinoid to alleviate menstrual cramps. There are also a wide market of cannabinoid-infused balms and lotions available as a topical pain relief aide. Individuals who are suffering from multiple sclerosis and other auto-immune debilitating conditions e.
As these diseases stem from inflammation of the inner lining of the digestive tracts, the anti-inflammatory ability of the cannabinoid can drastically provide suppression of the inflammation as well as pain relief for the intense pain associated with the damage.
But product sales and interest in CBD are hitting new heights. CBD is also turning up in everything from beauty products like lip balm and mascara to sodas, alcohol, and infused waters. In fact, one of the only studies to ever look directly at the effects of cannabidiol on blood sugar and insulin levels in people with diabetes found no benefits at all. They took one of the compounds, or a combination of the two, daily for 13 weeks.
CBD did seem to cause small changes in resistin, a protein that boosts inflammation and may be involved in insulin resistance; and glucose-dependent insulinotropic peptide hormone that stimulates insulin release.
Related Considering Pot for Pain? The research had been supported by the UK drug company GW Pharmaceuticals, which went on to develop Epidiolex for seizure disorders. So what about all the research cited online suggesting blood sugar benefits? Some mis-state the results of the UK study.
All link readers to small studies in animals, with results that have not been tested or not been replicated in people. Between and , the US Food and Drug Administration sent warning letters to companies that marketed CBD products, over claims and testimonials that oils and other products could treat diabetes and other conditions—including cancer. But they are turning up more and more frequently on other websites. Gottlieb said in a statement. In the study, researchers highlighted the successful use of CBD as a therapy on patients whose seizures had been non-responsive to prior treatments.
A group of 15 patients were given CBD for a period from one month to a year. They also experienced improvements in behavior, language, sleep, and eating habits. As well as witnessing an improvement in their mood after consuming CBD. Similar findings were reported on a study carried out on children suffering with Dravet Syndrome. Like those suffering from refractory epilepsies, traditional medications and treatments are only able to minimize the symptoms, if have any effect at all.
They carried out the study on children and young adults with Dravet syndrome and drug-resistant seizures. In the double blind study, participants received either a daily dose of CBD oral solution or a placebo over a week period. Researchers found the CBD-treated convulsive seizures almost halved from Whereas those taking the placebo experienced a decrease of only 0. Over 25 million people in the U. A study carried out last year investigated how CBD may reduce the fear response in sufferers.
The results showed CBD benefits can play an important role in helping sufferers manage their condition. In the study, researchers gave Wistar rats a small electric shock followed immediately by dose of CBD. The CBD lessened the formation of their specific and long-term memory of the electric shock.
In another study , researchers examined the effects of CBD on those suffering from panic disorder. A condition which affects approximately 6 million adults in the U. They explored the findings from previous studies, like anxiety in public speaking and electrical stimulation in animal subjects.
They found CBD benefits to be a promising potential treatment for panic disorders. This is great news for sufferers of panic and anxiety conditions who rely on psychiatric medications to manage their symptoms. A study has revealed CBD benefits include anti-inflammatory effect on sebaceous glands. This means it has potential to treat acne vulgaris.
Likewise, in a similar study they found CBD can treat psoriasis as it reduces the growth of skin cells. A study found CBD can reduce resting systolic blood pressure and stroke volume. In the study, nine healthy male participants received either mg of CBD or a placebo. Researchers witnessed a reduction in blood pressure when testing participants stress levels.
People suffering from chronic pain often become over-dependent on their medications. A study in , tried to solve this by finding an alternative to opioid based-medications. Researchers surveyed 2, cannabis-users who had been using an opioid medication for pain in the last six months. This is exciting news for sufferers of arthritis as it means it has the potential to treat the progression of their disease.
In another study in animal models, researchers revealed CBD can protect joints against severe damage, decreased progression, and improve symptoms of arthritis.
And the first controlled trial of the cannabis-based medicine Sativex showed exciting results. Researchers gave subjects the medicine over a 5-week period. They witnessed great reductions in pain intensity when moving and resting, as well as with their quality of sleep, and inflammation.
Diabetes and Marijuana: A Possible Treatment?
While the research on CBD and diabetes is relatively new, the majority of it is very Many studies have a shown a connection between chronic. RESEARCH DESIGN AND METHODS In this randomized, double-blind In rodent studies, CBD has multiple desirable effects in the context of. There are currently more than 75 human studies of cannabidiol that are this British study compared the effects of CBD and another cannabis.