Citation: Poutahidis T, Kleinewietfeld M, Smillie C, Levkovich T, Perrotta A, Bhela S, et al. () Microbial Reprogramming Inhibits Western. Citation: Levkovich T, Poutahidis T, Smillie C, Varian BJ, Ibrahim YM, Lakritz JR, et al. () Probiotic Bacteria Induce a 'Glow of Health'. Karagiannis GS, Poutahidis T, Erdman SE, Kirsch R, Riddell RH, Diamandis EPCancer-associated fibroblasts drive the progression of metastasis through both.
Female Sabra mice were injected with either saline or thioacetamide and were treated with either vehicle or cannabidiol. Neurological and motor functions were evaluated 2 and 3 days, respectively, after induction of hepatic failure, after which brains and livers were removed for histopathological analysis and blood was drawn for analysis of plasma liver enzymes.
In a separate group of animals, cognitive function was tested after 8 days and brain 5-HT levels were measured 12 days after induction of hepatic failure.
Neurological and cognitive functions were severely impaired in thioacetamide-treated mice and were restored by cannabidiol. Similarly, decreased motor activity in thioacetamide-treated mice was partially restored by cannabidiol. Increased plasma levels of ammonia, bilirubin and liver enzymes, as well as enhanced 5-HT levels in thioacetamide-treated mice were normalized following cannabidiol administration.
Likewise, astrogliosis in the brains of thioacetamide-treated mice was moderated after cannabidiol treatment. Cannabidiol restores liver function, normalizes 5-HT levels and improves brain pathology in accordance with normalization of brain function.
Therefore, the effects of cannabidiol may result from a combination of its actions in the liver and brain. Read Article at publisher's site. Or filter your current search. British Journal of Pharmacology [18 Sep , 3: Abstract Hepatic encephalopathy is a neuropsychiatric syndrome caused by liver failure. In view of the effects of cannabinoids in a thioacetamide-induced model of hepatic encephalopathy and liver disease and the beneficial effect of capsaicin a TRPV1 agonist in liver disease, we assumed that capsaicin may also affect hepatic encephalopathy.
Fulminant hepatic failure was induced in mice by thioacetamide and 24 h later, the animals were injected with one of the following compound s: Their neurological effects were evaluated on the basis of activity in the open field, cognitive function in an eight-arm maze and a neurological severity score. The mice were killed 3 or 14 days after thioacetamide administration. Capsaicin had a neuroprotective effect in this animal model as shown by the neurological score, activity and cognitive function.
The effect of capsaicin was blocked by capsazepine. Thioacetamide induced astrogliosis in the hippocampus and the cerebellum and raised brain 5-hydroxytryptamine levels, which were decreased by capsaicin, SRA and HU Thioacetamide lowered brain 2-arachidonoylglycerol levels, an effect reversed by capsaicin.
Brief Key Findings
Microbial symbionts accelerate wound healing via the neuropeptide hormone oxytocin. Poutahidis T(1), Kearney SM, Levkovich T, Qi P, Varian BJ, Lakritz JR. Levkovich T(1), Poutahidis T, Smillie C, Varian BJ, Ibrahim YM, Lakritz JR, Alm EJ , Erdman SE. Author information: (1)Division of Comparative. Lakritz JR, Poutahidis T, Levkovich T, Varian BJ, Ibrahim YM, Chatzigiagkos A, Mirabal S, Alm EJ, Erdman SE. Beneficial bacteria stimulate.