An introduction to the endogenous cannabinoid system .. glycerol is a full agonist through human type 2 cannabinoid receptor: antagonism by anandamide . May 16, All these systems make up the human body. the first to describe the structure and functional expression of the cannabinoid receptor, CB The endocannabinoid system (ECS) is a biological system composed of endocannabinoids, . In humans, cannabinoid receptors exist in much lower concentration in these regions, which helps explain why cannabinoids possess a greater.
System The Human Cannabinoid
Scientists from the University of Bonn have discovered this in experiments on mice. Their results will be published in the distinguished scientific journal Science on Friday, 8 June. The study may also have implications for therapy. In animal experiments, a solution with an important component made from cannabis reduced allergic reactions of the skin. Extracts of the hemp plant cannabis are traditionally used as a popular remedy against inflammation.
Both receptors are made such that THC can attach itself to them. In the brain this causes the intoxicating effect of hashish, cannabis and marijuana. But why does the body have CB1 and CB2 anyway" For two decades it has been known that the human body also produces its own cannabinoids. Like THC they can attach themselves to the receptors. The brain scientist Professor Andreas Zimmer from the Bonn Institute of Molecular Psychiatry is investigating what the function of this endocannabinoid system is.
However, according to these most recent results, endocannabinoids also seem to play an important part in regulating inflammation processes. As is often the case with important discoveries, coincidence was involved.
In scientific experiments mice are given an ear clip, so that researchers can tell them apart. The skin around the ear clips became inflamed. Together with the Bonn dermatologists Dr.
Skin rash can be caused by allergens in laboratory mice. We observed something similar when we blocked the receptors with medication. When inflammation occurs the endocannabinoids act like someone stepping on the brakes. They prevent the body from doing too much of a good thing and the immune reaction from getting out of control.
This is consistent with the fact that at the beginning of the infection the endocannabinoid concentration increased in the mice. In our experiments these animals also showed a less marked allergic reaction. The results open up new options for the treatment of skin allergies and inflammation. Firstly, drugs which prevent the breakdown of endocannabin-oids look promising.
But the old household remedy cannabis could also make a comeback as an ointment. In the experiment on mice this approach has already been successful. In this way the active substance reduces the allergic reaction.
University of Bonn Explore further. Please sign in to add a comment. Registration is free, and takes less than a minute. Your feedback will go directly to Science X editors. Thank you for taking your time to send in your valued opinion to Science X editors. Cacao powder contains three compounds that are structurally very similar to endocannabinoids.
The content of cannabinoid-like compounds in chocolate varies widely and is highest in dark chocolate and raw cacao. Other compounds in chocolate may be able to help prevent heart disease, stroke, and dementia. Numerous herbs and teas contain compounds that can enhance the ECS. Beta-caryophyllene is a terpene found in black pepper, lemon balm, hops, cloves, cannabis, oregano, cinnamon, and several other herbs. It selectively stimulates the CB2 receptor, a sought-after property in the development of treatments for inflammatory disorders.
Regular use of moderate to high quantities of alcohol can also impair the ECS  , so for optimal health and endocannabinoid function, please use moderation when drinking or avoid alcohol entirely. While chronic stress can deplete your ECS, a highly tuned ECS can protect you from the detrimental effects of stress .
Incorporating exercise into your daily routine will keep your ECS well-tuned, but only if you enjoy it! Animal studies teach us that if you force yourself to exercise, your ECS will interpret the activity as stress, but freely choosing and enjoying the same activity can have the opposite effect of stress and actually increase endocannabinoid levels.
Socializing can also be great for stress reduction and enhancing ECS function. Rats in social isolation produced less cannabinoid receptors, while social play and grooming behavior increased function of the ECS.
The wellness section at Healer. Endocannabinoids and their receptors are found throughout the body: In each tissue, the cannabinoid system performs different tasks, but the goal is always the same: Your body naturally produces its own cannabinoids.
Proper dosages of cannabis can also up-regulate and tonify your ECS. The plant, however, is not the only way to support your ECS. You can stimulate your ECS naturally with delicious endocannabinoid-enhancing foods and enjoyable activities which can lead to widespread health benefits.
Content for this article is based on the Introduction to Cannabis 4-day online course at Healer. Recognized as a leading clinician in the application of medical cannabis, Dr. Sulak is committed to providing education to clinicians and patients on the use of medical cannabis.
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The Science of the Endocannabinoid System: How THC Affects the Brain and the Body
Cannabinoid science. Medical marijuana research led to the discovery of The Endocannabinoid System, an important system in the human body. Dec 16, The endocannabinoid system plays many crucial roles in your body, and " Cannabinoid" comes from "cannabis," and "endo" is short for. Mar 7, Most people however, are unaware that the human body has its own system for processing and even creating its own cannabinoids known as.