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  • Design and participants Danish school children aged 8–10 years were cluster randomised to a small-sided ball game group (SSG) (n=96, four schools, five. We investigated the exercise intensity and fitness effects of frequent school- based low-volume high-intensity training for 10 months in 8–year-old children. J Sports Med Phys Fitness. Oct doi: /S [Epub ahead of print]. Fitness effects of one year soccer training of and.

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    Plasma homocysteine was quantified using HPLC with fluorometric detection. Statistical analyses were performed using SPSS A two-tailed P value of less than 0. Tests for normality were included in the model, and all data were found to be normally distributed.

    Differences between the time restricted feeding and control groups at baseline were analyzed by an independent samples t -test continues variables or the McNemar test categorical variables. Data were included for 46 participants, and means were estimated using an intention-to-treat analysis using last observation carried forward.

    Repeated measures two-factor ANOVA with groups time restricted feeding and control as the between-subject factor and time week 1 and 12 as the within-subject factor was used to compare changes in dependent variables between the groups over time. As portrayed in Fig. No subjects reported dropping out of the time restricted feeding group due to issues with the diet. Subjects in the time restricted feeding group were compliant with the prescribed eating window Weekly adherence to the 8-hour feeding window by the time restricted feeding group.

    Each bar indicates the mean number of days per week that the time restricted feeding subjects were compliant with the 8-hour feeding window. On average, the time restricted feeding group was compliant with the prescribed eating window Self-reported dietary intake, eating duration, and physical activity at baseline and week 12 1. Data for all variables were collected over a 7-d period at baseline prior to the commencement of the study and week 12 in the TRF and control groups.

    Data were included for 46 participants; means were estimated using an intention-to-treat analysis using last observation carried forward. No difference between groups for any parameter Independent samples t -test. Self-reported intake of macronutrients, dietary cholesterol and fiber did not differ between groups at baseline or post-treatment. Body weight remained stable during the 2-week baseline period Fig. Body weight decreased in the time restricted group —2. There were no statistically significant differences i.

    Weight loss by the time restricted feeding group versus controls 1. Body weight remained stable during the 2-week baseline period week B1 and week B2. Body composition and metabolic disease risk factors after 12 weeks 1. Homeostatic model assessment Insulin resistance; RMR: This study is the first trial to examine the impact of time restricted feeding on body weight and metabolic disease risk factors in an obese population. We show here that 12 weeks of 8-h time restricted feeding i.

    We also demonstrate that this fasting regimen produces significant reductions in systolic blood pressure relative to controls. Adherence to the time restricted feeding window was assessed daily via self-report. However, no one in the time restricted feeding group reported dropping out due to issues with the diet. These preliminary findings suggest that time restricted feeding may be somewhat well tolerated over short periods in obese subjects. This may be due, in part, to the shorter trial duration 3 months implemented here, when compared to the h time restricted feeding study 4 months [ 11 ].

    In comparison to other forms of intermittent fasting [ 4—10 ], time restricted feeding appears to produce less weight loss.

    We speculate that this difference in weight loss is due to greater overall caloric restriction achieved with other forms of intermittent fasting, versus time restricted feeding. The greater degree of energy restriction achieved with alternate day fasting is most likely the result of the vigilant calorie counting on fast days.

    Since time restricted feeding does not require subjects to monitor calorie intake at all, this may explain why the average caloric deficit achieved with time restricted feeding is lower. One potential confound in the current study is the lack of an objective measure to assess eating duration. As time restricted feeding is a recent concept, methods to objectively record eating time have yet to be optimized. Self-reporting of eating duration, as used in the current study, may not be optimal.

    Objective methods of recording eating events show a mean eating duration that is different from what is widely believed [ 11 ]. Our study also permitted the consumption of low energy drinks including coffee, tea, and diet soda. These drinks contain caffeine, which is known to perturb circadian rhythm [ 17 ].

    Since time restricted feeding is based on the principle of circadian rhythm regulation of metabolism, low-energy caffeinated drinks may not count significantly towards energy consumption, but can have significant impact on circadian regulation. Future trials in this area can be improved by using objective measures to better assess daily eating durations.

    Moreover, how the placement of the feeding window influences weight loss and adherence will also be important to examine. We chose to prescribe a feeding window of We assumed that this window would produce maximal adherence, as it would cause minimal disruption to the typical eating schedule i.

    However, recent trials [ 18, 19 ] have found that consuming larger meals earlier in the day produce better weight loss than similar sized meals consumed later in the evening. Whether weight loss and adherence can be improved by shifting the eating window earlier in the day warrants investigation. Metabolic disease risk indicators remained relatively unaffected by the time restricted feeding regimen.

    Systolic blood pressure was the only parameter that improved over the course of the study, relative to controls. Reductions in insulin, insulin resistance, triglycerides, and homocysteine were also observed over time, but these effects were not statistically different from the control group. In the study by Moro et al.

    It is likely that the degree of weight loss produced by 8-h time restricted feeding was not large enough to improve these outcome measures. It should also be noted that the obese subjects in the present study were metabolically healthy at baseline, i.

    Previous work indicates that intermittent fasting regimens [ 4, 8, 10 ] and other lifestyle regimens [ 21, 22 ] have little effect on cardiometabolic disease risk factors in healthy obese subjects. It will be of interest to examine whether time restricted feeding can improve these risk factors in other groups of obese patients, such as those with compromised insulin sensitivity or dyslipidemia [ 23, 24 ]. This study has several limitations. First, the study was not a randomized controlled trial.

    We compared the effects of time restricted feeding to a matched historical control group from a previous weight loss trial conducted by our group. The trial [ 10 ] from which the controls were selected was conducted between — As such, the lapse of up to five years between trials could have influenced what the control subjects knew about weight control, and what foods were available in the marketplace due to seasonality.

    These issues should be considered when interpreting the present findings. In order to truly determine the effect of time restricted feeding on body weight and other metabolic disease variables, future trials should implement a randomized design where controls are enrolled concurrently.

    Second, the study was quite short 12 weeks. If the material has been adapted instead of reproduced from the original RSC publication "Reproduced from" can be substituted with "Adapted from". In all cases the Ref. XX is the XXth reference in the list of references. If you are the author of this article you do not need to formally request permission to reproduce figures, diagrams etc.

    If you are the author of this article you still need to obtain permission to reproduce the whole article in a third party publication with the exception of reproduction of the whole article in a thesis or dissertation. Information about reproducing material from RSC articles with different licences is available on our Permission Requests page. Fetching data from CrossRef. This may take some time to load. Jump to main content.

    Jump to site search. You do not have JavaScript enabled. The periodic HD program of our hospital distributes patients in 6 groups of 10—12 patients. These groups perform sessions only in the high-flux HD modality with a 3. There were two comparative study phases with a duration of six weeks each. All patients with RLS were evaluated by the same neurologist.

    Patients who met 4 criteria were diagnosed of RLS. After an individualized explanation of the administration system, rotigotine transdermal patches were maintained for 24 h, with rotation of the application sites. In case of requiring dose reduction, this was done progressively to avoid a rebound effect on symptomatology.. At the beginning of the study, main demographic data were collected age, gender, ethiology of renal failure, vintage and associated comorbidities diabetes mellitus, arterial hypertension, peripheral vascular disease, ischemic heart disease, Charlson comorbidity index, smoking, alcohol habit, caffeine derivatives.

    Also, the following variables were analyzed.. It consists of 10 questions with 5 possible answers. Each answer is scored from 0 to 4.

    The simplest way to analyze the result is the sum of the total score. From 15 points up, it is considered severe symptomatology. The higher the score, the greater the severity. The QS assesses using a qualitative scale 1: Quality of life was assessed using an approved health questionnaire adapted to RLS: The simplest way to analyze the results is the sum of the total score. Overall, the higher the score, the poorer quality of life for a RLS patient. It consists of 2 sections; the first evaluates the nighttime sleep.

    It consists of 6 questions, 5 more specific and valued from 0 not to 3 much and a sixth question that is dedicated to global assessment with 7 possibilities from 0 very bad to 7 very good.

    In the second section daytime sleepiness is assessed. It consists of 6 specific questions valued from 0 never to 3 frequently. Compliance with the treatment was evaluated by reviewing the transdermal patch at the beginning of the HD session.

    Those patients who presented absence of the transdermal patch in 3 regular revisions were classified as noncompliant.. Adverse effects analyzed by anamnesis during the usual sessions of HD were: The statistical analysis was performed using the SPSS program version By Kolmogorov—Smirnov test the data did not present a normal distribution. The quantitative variables were expressed by means and standard deviation. The qualitative variables, by percentage.

    The quantitative data were compared using the Wilcoxon test for nonparametric related variables and the qualitative data using the McNemar test. A total of 66 patients prevalent in the HD program were analyzed. Five were excluded 3 had dementia, one did not accept to participate and another patient had a psychiatric disorder.

    Of the remaining 61 patients, 14 were diagnosed with RLS, with a prevalence of During the study period there were 5 dropouts one due to cardiorespiratory arrest, 3 due to revocation of informed consent and one due to malignant hematological disease , none of dropouts was the related to the present study.

    Of the 9 remaining patients, The average Charlson index was The main comorbidities were: The main etiology of chronic kidney disease was diabetes mellitus The rest of the etiologies are shown in Fig. Among the potential triggers, No significant differences were observed in the main biochemical parameters and HD adequacy in both phases of the study Table 1.

    Similarly, no changes were made in the patient's usual medication related to RLS during the study No patient was taking levodopa, clonidine, gabapentin, l -carnitine or antiemetics.

    Biochemical parameters and adequacy of hemodialysis.. No significant differences were found between the groups studied.. The values of the main variables analyzed in the different phases of the study are shown in Table 2. Regarding the severity of the symptoms, No relevant changes were observed in the GRLS scale Results expressed as mean standard deviation , initial vs.

    John Hopkins restless leg syndrome quality of life; QS: During phase 2 of the study, we observed a significant improvement in GRLS No allergic reactions were observed in the application area. None of the patients in our study presented augmentation effect..

    Overall, after the introduction of rotigotine phase 2 , we observed a significant improvement in terms of quality of life related to SPI JH-QoL Table 3 shows the difference of means of the main variables in the different phases of the study. There was a significant improvement in terms of severity of symptoms 1.

    Analysis of differences between study groups.. Analysis of the mean changes of the main variables between the study groups. Results expressed as mean standard deviation.. Analysis using the nonparametric statistical test U of Mann—Whitney.. In these patients, the use of rotigotine improved the clinical symptoms, quality of life and sleep habits; it is a safe drug, with minimal adverse effects and complete therapeutic compliance.. The prevalence of RLS in our HD unit, it is practically the same as previously described in the literature 4, Patients with RLS have a decreased in life quality with depression and anxiety as well as a abnormalities in sleep habits producing daytime sleepiness and fatigue.

    The presence of all these symptoms affected quality of life and sleep habits.. Currently, therapy with non-ergotamine dopamine agonists has become the first-line of therapy for moderate-severe involvement of RLS. The most commonly used medications are pramipexole, ropinirole and, more recently, rotigotine.

    Main randomized clinical trials with pharmacological intervention in patients with restless legs syndrome in renal replacement therapy.. Within this group of drugs, the use of rotigotine has been extended in the every day practice due to the efficacy, good tolerance, few adverse effects, low prevalence of paradoxical potentiation of symptoms or augmentation effect and no need for dose adjustment in CKD patients.

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    Here we report our investigations on the binding interactions of a NDI diammonium dichloride salt (NDI·Cl2) with cucurbit[n]uril (CB[n], n = 8, 10) and the. Although aware of the negative effect of smoke on their own health, only 20% of BMC International Health and Human Rights Prenatal Music Exposure Induces Long-Term Neural Effects PLoS ONE 8(10): e westernkentuckyvsfloridaintllive.us

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    Here we report our investigations on the binding interactions of a NDI diammonium dichloride salt (NDI·Cl2) with cucurbit[n]uril (CB[n], n = 8, 10) and the.


    Although aware of the negative effect of smoke on their own health, only 20% of BMC International Health and Human Rights


    Prenatal Music Exposure Induces Long-Term Neural Effects PLoS ONE 8(10): e westernkentuckyvsfloridaintllive.us


    Effects of ACh (10 −8, 3 × 10 −8, 10 −7, 3 × 10 −7, and 10 −6 M) on the pulmonary vascular resistance in rabbit isolated lungs pretreated with U


    Download scientific diagram | Effects of PGE1 ( mg/ml) and Helymext ( mg/ml) in the absence and in the presence of indomethacin (


    Purpose: To assess anatomical and functional effects of long duration dive (8 and 10 hours) on the eye, by reproducing all the constraints undergone by.


    Premiere Edition Volumes Sound Effects. GBs of Sound Effects from Alan Howarth. We are proud to add legendary sound designer Alan Howarth's.

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