Check out these facts about CBD and diabetes to see how this plant can help. Are there also connections between CBD and diabetes prevention and treatment ? cannabinoid, CBD does not come with any mind-altering effects. There are a number of positive links between CBD oil and diabetes. It can be managed, with CBD oil and conventional treatments and with Diabetes is the term used to describe a range of diseases that involve CBD is a cannabinoid that interacts with cannabinoid receptors in the body. However, the anti-inflammatory effects of cannabidiol have been well-researched. October 24, By admin Comments are Off cannabis oil medical benefits, new alzheimer's And of course, there is a lot of information about diabetes treatment and The impact of diabetes in Canada is alarming, especially with the CBD is developing a great reputation for helping with many diseases and disorders.
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Although direct involvement of the ECS has not yet been proven in diabetic cardiomyopathy, the plant-derived cannabinoid CBD attenuates inflammation, oxidative stress, cell death, myocardial dysfunction, and fibrosis in a diabetic cardiomyopathy model.
The first direct indication that the ECS plays an important role in the pathogenesis of diabetic nephropathy came from a murine model of metabolic syndrome. This effect was concurrent with a delay in the progression of renal failure as shown by the prevention of the development of proteinuria, improved creatinine clearance, and reduction of glomerular injury and renal hypertrophy compared with vehicle-treated rats.
Similarly, RIO was also able to reduce the albumin-creatinine ratio and glomerular sclerosis in a prediabetic rat model of metabolic syndrome.
The selective CB 1 antagonist AM reduced proteinuria by preventing a decrease in the mRNA and protein levels of the slit diaphragm molecules nephrin, podocin, and zonula occludens-1 in diabetic kidneys. CB 2 agonists ameliorated albuminuria, podocyte protein down-regulation, and glomerular monocyte infiltration without affecting early markers of fibrosis and reduced chemokine receptor-2 expression in both the renal cortex and cultured podocytes, suggesting that CB 2 receptor activation may interfere with the deleterious effects of MCP-1 signaling.
The CB 2 receptor was down-regulated in kidney biopsy specimens from patients with advanced diabetic nephropathy, and renal levels of the CB 2 ligand 2-AG were reduced in diabetic mice, suggesting impaired CB 2 signaling.
The in vivo results were supported by in vitro findings that provided more mechanistic insight as to how the ECS influences the pathogenesis of renal failure in diabetes and the role of tubular processes in the effects of ECs during the development of diabetic kidney damage. In vitro , AEA significantly increases the hypertrophy of proximal tubular cells. In another study, the hyperlipidemia-induced tubular cell dysfunction observed in diabetic kidneys was modeled by palmitic acid—induced apoptosis in HK-2 cells.
Blockade of CB 1 receptors was able to ameliorate palmitic acid—induced endoplasmic reticulum stress and the subsequent apoptosis. Diabetes is the leading cause of new cases of blindness and preventable blindness among adults. Vascular inflammation and endothelial cell death caused by oxidative and nitrative stress are characteristics of diabetic retinopathy. The role of such an increase gained importance when we received insight into the role of CB 1 receptor activation in diabetic retinopathy.
Deletion of the CB 1 receptor or treatment with a CB 1 receptor antagonist prevented retinal cell death in a murine diabetes model. These observations were supported by the fact that hyperglycemia up-regulated CB 1 receptor expression and induced apoptosis in retina pigment epithelial cells, effects that were preventable with a CB 1 receptor antagonist.
The effect of CBD was also examined in experimental diabetic retinopathy. CBD was able to reduce oxidative stress, inflammation, cell death, and vascular hyperpermeability associated with diabetes. Furthermore, CBD also attenuated high glucose—induced endothelial cell dysfunction, ROS generation, and barrier disruption in primary human coronary artery endothelial cells.
CB 1 receptors are widely expressed throughout the central and peripheral nervous systems, whereas CB 2 receptors are primarily restricted to the cells of the peripheral nervous system, microglia, and dorsal horn neurons. ECs are retrograde messengers with agonistic activity on presynaptic CB 1 receptors, slowing neurotransmission.
A good example of this effect is the suppression of nociceptive transmission in the periphery at the level of the posterior horn of the spinal cord. The first indication of the role of the ECS in diabetic neuropathy came from a murine diabetes model.
Mechanical allodynia in diabetic rats can also be attenuated by treatment with a nonselective cannabinoid agonist. Both in vitro and in vivo findings regarding the role of cannabinoid receptors in the pathogenesis of diabetic peripheral neuropathy are contradictory. CB 1 receptor expression has been shown to be down-regulated in PC cells exposed to high glucose levels and in dorsal root ganglia removed from diabetic rats 97 ; the synthetic cannabinoid HU was able to restore impaired nerve growth factor—induced neurite outgrowth in cells exposed to high glucose levels in a CB 1 receptor—dependent manner, 98 consistent with the earlier finding that HU attenuates neural damage.
The natural cannabinoid CBD offers a further possible therapeutic advantage because it was able to attenuate the development of neuropathic pain. This effect was associated with the restriction in the elevations of microglial density in the spinal cord and of phosphorylated pMAPK.
Although there is much controversy in the field of EC research, experimental evidence and clinical trials have clearly shown that ECS plays a key role in the development of primary diabetes and various diabetic complications.
Although inhibition of CB 1 receptors has proven to be effective in clinical trials of obesity and metabolic syndrome, this approach has ultimately failed because of increasing patient anxiety. However, recent preclinical studies clearly showed that peripherally restricted CB 1 antagonists may represent a viable therapeutic strategy to avoid the previously mentioned adverse effects. The main effects of CB 1 receptor activation on the development of diabetes and diabetic complications are summarized in Figure 1.
CB 2 agonists may exert beneficial effects on diabetes and diabetic complications by attenuating inflammatory response and ensuing oxidative stress Figure 2.
CBD is a potent antioxidant and anti-inflammatory agent that does not appear to exert its beneficial effects through conventional CB receptors and is already approved for human use. THCV and its derivatives, which may combine the beneficial effects of simultaneous CB 1 inhibition and CB 2 stimulation, are still under intense preclinical investigation.
We hope that some of these new approaches will be useful in clinical practice in the near future to aid patients with diabetes. Effects of CB 1 receptor activation on diabetes and diabetic complications. CB 1 receptor activation may indirectly via its metabolic consequences or directly enhance diabetes-associated inflammation and ROS generation, promoting tissue injury and the development of diabetic complications. Possible beneficial effects of CB 2 receptor activation on diabetes and diabetic complications.
CB 2 receptor stimulation may exert beneficial effects against various diabetic complications by attenuating high glucose—induced endothelial cell activation and inflammatory response; chemotaxis, transmigration, adhesion, and activation of inflammatory cells; and subsequent proinflammatory responses and ROS generation.
We are indebted to Dr. Raphael Mechoulam for critically reading the paper and making valuable suggestions. We apologize to colleagues whose important work may not be covered due to the brief nature of this review.
None of the authors disclosed any relevant financial relationships. National Center for Biotechnology Information , U. Journal List Am J Pathol v. Author information Article notes Copyright and License information Disclaimer. Accepted Nov 2. Published by Elsevier Inc. This document may be redistributed and reused, subject to certain conditions. This article has been cited by other articles in PMC. Abstract Oxidative stress and inflammation play critical roles in the development of diabetes and its complications.
Role of the ECS in Diabetes and Diabetic Complications Primary Diabetes Diabetes is characterized by hyperglycemia caused by either a lack of insulin due to autoimmune destruction of islet cells or insulin resistance. Cardiovascular Complications Accurate glucose, blood pressure, and plasma lipid controls, as well as preventive care practices, are effective in reducing the number of complications in certain patient cohorts with diabetes; however, they have their own limitations.
Diabetic Retinopathy Diabetes is the leading cause of new cases of blindness and preventable blindness among adults. Conclusion and Perspectives Although there is much controversy in the field of EC research, experimental evidence and clinical trials have clearly shown that ECS plays a key role in the development of primary diabetes and various diabetic complications. Open in a separate window.
Acknowledgments We are indebted to Dr. The endocannabinoid system as an emerging target of pharmacotherapy. Receptors and channels targeted by synthetic cannabinoid receptor agonists and antagonists. International Union of Basic and Clinical Pharmacology: Is lipid signaling through cannabinoid 2 receptors part of a protective system?
The endocannabinoid system and its therapeutic exploitation. Nat Rev Drug Discov. Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. Curr Opin Investig Drugs.
Cannabidiol lowers incidence of diabetes in non-obese diabetic mice. Cannabidiol arrests onset of autoimmune diabetes in NOD mice. Neuroprotective and blood-retinal barrier-preserving effects of cannabidiol in experimental diabetes. Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barrier disruption. Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy.
J Am Coll Cardiol. Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress. Free Radic Biol Med. The plant cannabinoid Delta9-tetrahydrocannabivarin can decrease signs of inflammation and inflammatory pain in mice. Centers for Disease Control and Prevention. Centers for Disease Control and Prevention; Atlanta: National Diabetes Fact Sheet. The global burden of diabetes and its complications: Eur J Cardiovasc Prev Rehabil.
Oxidative stress and diabetic complications. Nitric oxide and peroxynitrite in health and disease. Leptin-regulated endocannabinoids are involved in maintaining food intake.
Activation of the peripheral endocannabinoid system in human obesity. The endocannabinoid system in obesity and type 2 diabetes. The case for peripheral CB 1 receptor blockade in the treatment of visceral obesity and its cardiometabolic complications. Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia.
N Engl J Med. Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients: Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity. Role of cannabinoid CB2 receptors in glucose homeostasis in rats.
Endocannabinoid dysregulation in the pancreas and adipose tissue of mice fed with a high-fat diet. Obesity Silver Spring ; Expression and function of cannabinoid receptors in mouse islets. The cannabinoid CB1 receptor is expressed in pancreatic delta-cells. Biochem Biophys Res Commun. CB1 cannabinoid receptor expression is regulated by glucose and feeding in rat pancreatic islets. Presence of functional cannabinoid receptors in human endocrine pancreas.
Regulation, function, and dysregulation of endocannabinoids in models of adipose and beta-pancreatic cells and in obesity and hyperglycemia. J Clin Endocrinol Metab. Cannabinoid receptors are coupled to stimulation of insulin secretion from mouse MIN6 beta-cells. Efficacy and tolerability of rimonabant in overweight or obese patients with type 2 diabetes: Effect of rimonabant on glycemic control in insulin-treated type 2 diabetes: Differential alterations of the concentrations of endocannabinoids and related lipids in the subcutaneous adipose tissue of obese diabetic patients.
Lipids Health Dis [Internet] ; 9: Cannabinoid-based drugs as anti-inflammatory therapeutics. Examination of the immunosuppressive effect of delta9-tetrahydrocannabinol in streptozotocin-induced autoimmune diabetes. A study found that CBD treatment significantly reduced the incidence of diabetes in non-obese diabetic mice from an incidence of 86 percent in non-treated mice to an incidence of 30 percent in CBD-treated mice.
A histological examination of the pancreatic islets of the CBD-treated mice revealed significantly reduced insulitis. In , the American Journal of Medicine published a study that highlighted the impact of marijuana use on glucose, insulin and insulin resistance among U. The study included 4, adult men and women from the National Health and Nutritional Examination Survey from to Of the participants, were current marijuana users and 1, were past users.
The researchers found that current marijuana use was associated with 16 percent lower fasting insulin levels. They also found significant associations between marijuana use and smaller waist circumferences, a factor connected to the onset of diabetes symptoms.
A study published in the British Journal of Clinical Pharmacology reports that CBD protects against the vascular damage caused by a high glucose environment, inflammation or the induction of type 2 diabetes in animal models; plus, CBD proved to reduce the vascular hyperpermeability which causes leaky gut associated with such environments. As the popularity of CBD products continues to grow, more manufacturers are jumping on the bandwagon. This can be a great thing for consumers who are looking to get the best CBD products out there.
But it also requires careful research before making a purchase. Although the research on the medicinal use of cannabis is strong, several studies indicate that the recreational use of cannabis can have persistent adverse effects on mental health. Most recreational users will never be faced with such persistent mental illness, but in some individuals cannabis use leads to undesirable effects, including cognitive impairment, anxiety, paranoia and increased risks of developing chronic psychosis or drug addiction.
Some studies show that CBD can counteract these adverse effects, but more research is needed, as most of this research is done on animals or is based on anecdotal reports. There are several ways to use CBD, including in capsule, topical, edible or drop forms.
I recommend ingesting CBD oil using a dropper because this is the easiest way to stay in control of exactly how much you are taking. Plus, pure CBD oil will not contain additives that come with side effects.
Remember, when you are using CBD oil or any kind of cannabis product, you must read the product label to determine the best dose for you. Where do you buy CBD oil? You may have noticed that CBD products are everywhere these days. To separate the highest quality products from the rest, look for one that has a certificate of analysis, or COA. This means that the manufacture tests the product for contaminants, and it meets lab standards.
I recommend avoiding vape pens because many contain a solvent called propylene glycol. When you burn this solvent at high temperatures, it can degrade into formaldehyde and cause danger adverse reactions. CBD is one of over 60 compounds found in cannabis that belong to a class of ingredients called cannabinoids; it is the major nonpsychoactive component of Cannabis sativa. Research shows that CBD benefits include its ability to act as an anti-inflammatory, anticonvulsant, antioxidant, antiemetic, anxiolytic and antipsychotic agent.
It is a potential medicine for the treatment of neuroinflammation, epilepsy, oxidative injury, vomiting and nausea, anxiety and schizophrenia.
CBD derived from industrial hemp is legal across the U. However, e ach state has specific requirements and conditions that need to be followed in order to use marijuana-derived CBD legally. Josh Axe is on a mission to provide you and your family with the highest quality nutrition tips and healthy recipes in the world The most common types of CBD available include: Tinctures are the most popular way to use CBD oil, likely because you can easily gauge exactly how much CBD you are ingesting.
A tincture is usually extracted using pressurized CO2 gas or a solvent. With a tincture, you use a dropper and place the drops under your tongue. These tend to be the most pure products. Sometimes, manufacturers will use carrier oils, natural flavors or fatty oils. Like tinctures, CBD concentrates are ingested by placing drops under your tongue. But concentrates are typically much stronger doses of CBD.
Like any other type of capsule, CBD capsules or pills can be taken with water. This is a convenient way to use CBD, but it gives you less control of the dose. Typically, capsules will contain 10—25 milligrams of CBD. Topical CBD products include lotions, salves and lip balms.
CBD patches are also available for topical delivery of the compound. This allows the cannabinoids to be delivered directly to your bloodstream. CBD edibles, including chocolates, coffees, baked goods, gums and candies containing the compound, are becoming popular. Although this may be a satisfying way to use CBD oil, it can be more difficult to measure exactly how much CBD you are ingesting and the results may be inconsistent.
This requires the use of an e-cigarette or vape pen, which can have side effects when chemicals are heated to high temperatures. There are also CBD waxes available that are used for dabbing the cannabis compound. This also requires heating a small amount of the wax and using a dabbing pen. Sprays are another product for using CBD internally. The CBD concentration is usually lower in sprays. Read the label for the exact dosage, but usually you spray the solution into your mouth 2—3 times.
Cannabis Oil What about cannabis oil? CBD Oil Benefits 1. Reduces Anxiety Studies using animal models of anxiety and involving healthy volunteers clearly suggest an anxiolytic-like effect of CBD. Relieves Nausea Cannabis has been used for centuries for the suppression of nausea and vomiting. Lowers Incidence of Diabetes A study found that CBD treatment significantly reduced the incidence of diabetes in non-obese diabetic mice from an incidence of 86 percent in non-treated mice to an incidence of 30 percent in CBD-treated mice.
Promotes Cardiovascular Health A study published in the British Journal of Clinical Pharmacology reports that CBD protects against the vascular damage caused by a high glucose environment, inflammation or the induction of type 2 diabetes in animal models; plus, CBD proved to reduce the vascular hyperpermeability which causes leaky gut associated with such environments. Here are a few tips to help you choose a CBD oil product and determine the best dose for you: Start with a small dose and work your way up if needed.
Some people are more sensitive to cannabis compounds than others. Be aware of your desired effect when you start using CBD oil. You can usually take smaller doses if you are looking to boost your mood, improve sleep, reduce stress and relieve headaches or nausea. If you know exactly what you are looking for from using CBD oil, then it will be easier for you to determine the proper dose.
Final Thoughts About CBD Oil CBD is one of over 60 compounds found in cannabis that belong to a class of ingredients called cannabinoids; it is the major nonpsychoactive component of Cannabis sativa. CBD oil is available in many forms.
You can find products that provide CBD as a tincture, concentrate, capsule, topical solution, wax, edible and patch. More Natural Remedies Posts Dr. Axe on Facebook 22 Dr. Axe on Twitter 22 Dr. Axe on Instagram Dr. Axe on Google Plus Dr. Axe on Youtube Dr. Axe on Facebook 1 Dr. Collagen has become a popular ingredient that is now commonly found in
The Endocannabinoid System and Plant-Derived Cannabinoids in Diabetes and Diabetic Complications
In regard to CBD oil for diabetes, there are two main things to In what ways might CBD work to alleviate the spectrum of side effects caused by irregular blood sugar levels Conventional, Non-CBD Treatment Methods for Diabetes . it contains hardly any THC, which is the cannabinoid responsible for. Although diabetes has no cure, you can take steps to manage your diabetes and stay Effects of Full-Spectrum Cannabis Hemp Oil with CBD (cannabidiol) as a. Cannabidiol is a popular natural remedy used for many common cannabis plant, then diluting it with a carrier oil like coconut or hemp . Summary Some studies suggest that CBD may be an effective treatment for diabetes.